| Registro completo |
| Provedor de dados: |
ArchiMer
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| País: |
France
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| Título: |
Antiviral Activities of Sulfated Polysaccharides Isolated from Sphaerococcus coronopifolius (Rhodophytha, Gigartinales) and Boergeseniella thuyoides (Rhodophyta, Ceramiales)
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| Autores: |
Bouhlal, Rhimou
Haslin, Camille
Chermann, Jean-claude
Colliec-jouault, Sylvia
Sinquin, Corinne
Simon, Gaelle
Cerantola, Stephane
Riadi, Hassane
Bourgougnon, Nathalie
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| Data: |
2011-07
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| Ano: |
2011
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| Palavras-chave: |
Herpes simplex virus
Human immunodeficiency virus
Antiviral activity
Sulfated polysaccharide
S. coronopifolius
B. thuyoides
Chemical composition
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| Resumo: |
Water-soluble sulfated polysaccharides isolated from two red algae Sphaerococcus coronopifolius (Gigartinales, Sphaerococcaceae) and Boergeseniella thuyoides (Ceramiales, Rhodomelaceae) collected on the coast of Morocco inhibited in vitro replication of the Human Immunodeficiency Virus (HIV) at 12.5 mu g/mL. In addition, polysaccharides were capable of inhibiting the in vitro replication of Herpes simplex virus type 1 (HSV-1) on Vero cells values of EC(50) of 4.1 and 17.2 mu g/mL, respectively. The adsorption step of HSV-1 to the host cell seems to be the specific target for polysaccharide action. While for HIV-1, these results suggest a direct inhibitory effect on HIV-1 replication by controlling the appearance of the new generations of virus and potential virucidal effect. The polysaccharides from S. coronopifolius (PSC) and B. thuyoides (PBT) were composed of galactose, 3,6-anhydrogalactose, uronics acids, sulfate in ratios of 33.1, 11.0, 7.7 and 24.0% (w/w) and 25.4, 16.0, 3.2, 7.6% (w/w), respectively.
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| Tipo: |
Text
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| Idioma: |
Inglês
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| Identificador: |
http://archimer.ifremer.fr/doc/00060/17120/14631.pdf
DOI:10.3390/md9071187
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| Editor: |
Mdpi Ag
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| Relação: |
http://archimer.ifremer.fr/doc/00060/17120/
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| Formato: |
application/pdf
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| Fonte: |
Marine Drugs (1660-3397) (Mdpi Ag), 2011-07 , Vol. 9 , N. 7 , P. 1187-1209
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| Direitos: |
2011 MDPI
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